This work sought to optimize the extraction of seized cannabis by supercritical carbon dioxide fluid extraction (SFE). Due to its low water solubility, the cannabis extract was prepared as a self-emulsifying drug delivery system (SEDDS) to enhance its dissolution. The highest cannabidiol and ∆⁹-tetrahydrocannabinol contents were achieved at 18 MPa and 40 °C without the use of ethanol. The SEDDS droplet size, polydispersity index, D10, D50, D90, span, zeta potential, and emulsification time were evaluated to identify the formulation with minimized droplet size and emulsification time. The optimal formulation was composed of a 45:40:20 mass ratio of (2:1 Tween® 80:Span® 80):coconut oil:cannabis extract. The optimized SEDDS successfully enhanced the dissolution of cannabis extract obtained from SFE.

这项工作旨在通过超临界二氧化碳流体萃取 (SFE) 来优化对缉获大麻的萃取。由于其水溶性低，大麻提取物被制备为自乳化药物递送系统 (SEDDS) 以提高其溶解度。在不使用乙醇的情况下，在 18 MPa 和 40 °C 下实现了最高的大麻二酚和 Δ ⁹ -四氢大麻酚含量。评估 SEDDS 液滴尺寸、多分散指数、D10、D50、D90、跨度、zeta 电位和乳化时间，以确定具有最小液滴尺寸和乳化时间的制剂。最佳配方由质量比为 45:40:20 的（2:1 Tween® 80:Span® 80）：椰子油：大麻提取物组成。优化的 SEDDS 成功地增强了从 SFE 中获得的大麻提取物的溶解。