Targeted therapy and early accurate detection of malignant lesions are essential for the effectiveness of treatment and prognosis in cancer patients. The development of gaseous system as a versatile platform for the fabricated nanobubbles, has attracted much interest in improving the efficacy of ultrasound therapeutic, diagnostic, and theranostic platforms. Nano-sized bubble, as an ultrasound contrast agent, with spherical gas-filled structures exhibited contrast enhancement capability due to their inherent EPR effect. Additionally, nanobubbles exhibited good stability with extended retention time in the blood stream. The current review summarized various nanobubbles and discussed about the crucial parameters affecting the stability of ultrafine bubbles. Furthermore, therapeutic and theranostic gaseous systems for fighting against cancer were described.

靶向治疗和早期准确检测恶性病变对于癌症患者的治疗和预后的有效性至关重要。气体系统作为制造纳米气泡的多功能平台的发展引起了人们对提高超声治疗、诊断和治疗诊断平台功效的极大兴趣。纳米气泡作为超声造影剂，具有球形充气结构，由于其固有的 EPR 效应而表现出对比度增强能力。此外，纳米气泡表现出良好的稳定性，延长了在血流中的保留时间。目前的综述总结了各种纳米气泡，并讨论了影响超细气泡稳定性的关键参数。此外，