Gold-Catalyzed Reaction of Propargyl Esters and Alkynylsilanes: Synthesis of Vinylallene Derivatives through a Twofold 1,2-Rearrangement,Angewandte Chemie International Edition

当前位置： X-MOL 学术 › Angew. Chem. Int. Ed. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Gold-Catalyzed Reaction of Propargyl Esters and Alkynylsilanes: Synthesis of Vinylallene Derivatives through a Twofold 1,2-Rearrangement
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2021-09-28 , DOI: 10.1002/anie.202110783
Olaya Bernardo ₁ , Silvia González-Pelayo ₁ , Israel Fernández ₂ , Luis A López ₁

Affiliation

An efficient synthesis of structurally complex allenylsilanes through gold-catalyzed coupling of propargyl esters with alkynylsilanes is described. DFT calculations support a stepwise pathway consisting of two 1,2-rearrangements (acyloxy and silyl). A preliminary study on the enantioselective version would demonstrate its feasibility (er up to 95:5).