Catalytic Asymmetric Alkynylation of 3,4-Dihydro-β-carbolinium Ions Enables Collective Total Syntheses of Indole Alkaloids,Angewandte Chemie International Edition

当前位置： X-MOL 学术 › Angew. Chem. Int. Ed. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Catalytic Asymmetric Alkynylation of 3,4-Dihydro-β-carbolinium Ions Enables Collective Total Syntheses of Indole Alkaloids
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2021-09-28 , DOI: 10.1002/anie.202112383
Lixin Liang ₁ , Shiqiang Zhou ₁ , Wei Zhang ₁ , Rongbiao Tong _{1,

2}

Affiliation

Catalytic asymmetric alkynylation of 3,4-dihydro-β-carbolinium ions was developed for the versatile synthesis of enantiomerically enriched C1-alkynyl tetrahydro-β-carbolines, the utility of which was demonstrated by concise collective total syntheses of the seven indole alkaloids harmicine, geissoschizol, geissoschizine, akuammicine, desethyleburnamonine, eburnamonine, and larutensine within 10 steps (see scheme).

中文翻译：

3,4-二氢-β-咔啉离子的催化不对称炔化使吲哚生物碱的集体全合成成为可能

开发了 3,4-二氢-β-咔啉离子的催化不对称炔化作用，用于合成富含对映异构体的 C1-炔基四氢-β-咔啉，其效用已通过七种吲哚生物碱甘草碱的简明集体全合成证明， geissoschizol、geissoschizine、akuammicine、desethyleburnamonine、eburnamonine 和 larutensine 在 10 个步骤内（见方案）。

更新日期：2021-11-08

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11