Background The number of adults across the globe with significant depressive symptoms has grown substantially during the COVID-19 pandemic. The extant literature supports exercise as a potent behaviour that can significantly reduce depressive symptoms in clinical and non-clinical populations. Objective Using a suite of mobile applications, at-home exercise, including high intensity interval training (HIIT) and/or yoga, was completed to reduce depressive symptoms in the general population in the early months of the pandemic. Methods A 6-week, parallel, multiarm, pragmatic randomised controlled trial was completed with four groups: (1) HIIT, (2) Yoga, (3) HIIT+yoga, and (4) waitlist control (WLC). Low active, English-speaking, non-retired Canadians aged 18–64 years were included. Depressive symptoms were measured at baseline and weekly following randomisation. Results A total of 334 participants were randomised to one of four groups. No differences in depressive symptoms were evident at baseline. The results of latent growth modelling showed significant treatment effects in depressive symptoms for each active group compared with the WLC, with small effect sizes (ESs) in the community-based sample of participants. Treatment groups were not significantly different from each other. Effect sizes were very large (eg, week 6 ES range=−2.34 to −2.52) when restricting the analysis only to participants with high depressive symptoms at baseline. Conclusions At-home exercise is a potent behaviour to improve mental health in adults during the pandemic, especially in those with increased levels of depressive symptoms. Promotion of at-home exercise may be a global public health target with important personal, social and economic implications as the world emerges scathed by the pandemic. Trial registration number [NCT04400279][1]. Data are available in a public, open access repository. All of the individual participant data collected during the trial after de-identification, and reported in the manuscript, will be available at https://osf.io/g9xqp following publication. All of the protocols, statistical analysis plan, informed consent form, analytic code, will be available 4 months following trial's end. . [1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT04400279&atom=%2Fbjsports%2F56%2F10%2F546.atom

中文翻译：

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COVID-19 大流行和运动 (COPE) 试验：一项多组实用随机对照试验，检查基于应用程序的家庭锻炼计划对抑郁症状的影响

背景 在 COVID-19 大流行期间，全球出现严重抑郁症状的成年人数量大幅增加。现有文献支持锻炼作为一种有效的行为，可以显着减少临床和非临床人群的抑郁症状。目标 使用一套移动应用程序，完成了包括高强度间歇训练 (HIIT) 和/或瑜伽在内的在家锻炼，以在大流行的最初几个月减少普通人群的抑郁症状。方法 一项为期 6 周、平行、多组、实用的随机对照试验完成了四组：（1）HIIT，（2）瑜伽，（3）HIIT+瑜伽，和（4）候补名单控制（WLC）。包括 18-64 岁的低活跃、讲英语、未退休的加拿大人。在基线和随机分组后每周测量抑郁症状。结果共有 334 名参与者被随机分配到四组之一。基线时抑郁症状没有明显差异。潜伏生长模型的结果显示，与 WLC 相比，每个活跃组对抑郁症状的治疗效果显着，在基于社区的参与者样本中效果大小 (ESs) 较小。治疗组彼此之间没有显着差异。当仅将分析限制在基线时具有高度抑郁症状的参与者时，效应量非常大（例如，第 6 周的 ES 范围=-2.34 到 -2.52）。结论 在家锻炼是在大流行期间改善成年人心理健康的有效行为，尤其是那些抑郁症状水平增加的人。随着世界因大流行而受到重创，促进在家锻炼可能是一项具有重要个人、社会和经济影响的全球公共卫生目标。试用注册号 [NCT04400279][1]。数据可在公共、开放访问的存储库中获得。在去识别化后的试验期间收集并在手稿中报告的所有个体参与者数据将在发布后在 https://osf.io/g9xqp 上提供。所有方案、统计分析计划、知情同意书、分析代码将在试验结束后 4 个月提供。. [1]：/lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT04400279&atom=%2Fbjsports%2F56%2F10%2F546.atom 随着世界受到大流行病的严重影响，社会和经济影响。试用注册号 [NCT04400279][1]。数据可在公共、开放访问的存储库中获得。在去识别化后的试验期间收集并在手稿中报告的所有个体参与者数据将在发布后在 https://osf.io/g9xqp 上提供。所有方案、统计分析计划、知情同意书、分析代码将在试验结束后 4 个月提供。. [1]：/lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT04400279&atom=%2Fbjsports%2F56%2F10%2F546.atom 随着世界受到大流行病的严重影响，社会和经济影响。试用注册号 [NCT04400279][1]。数据可在公共、开放访问的存储库中获得。在去识别化后的试验期间收集并在手稿中报告的所有个体参与者数据将在发布后在 https://osf.io/g9xqp 上提供。所有方案、统计分析计划、知情同意书、分析代码将在试验结束后 4 个月提供。. [1]：/lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT04400279&atom=%2Fbjsports%2F56%2F10%2F546.atom 并在手稿中报告，出版后将在 https://osf.io/g9xqp 上提供。所有方案、统计分析计划、知情同意书、分析代码将在试验结束后 4 个月提供。. [1]：/lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT04400279&atom=%2Fbjsports%2F56%2F10%2F546.atom 并在手稿中报告，出版后将在 https://osf.io/g9xqp 上提供。所有方案、统计分析计划、知情同意书、分析代码将在试验结束后 4 个月提供。. [1]：/lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT04400279&atom=%2Fbjsports%2F56%2F10%2F546.atom