Multiple myeloma (MM) is a common malignant tumor of plasma cells. Despite several treatment approaches in the past two decades, MM remains an aggressive and incurable disease in dire need of new treatment strategies. Approximately 70–80% of patients with MM have myeloma bone disease (MBD), often accompanied by pathological fractures and hypercalcemia, which seriously affect the prognosis of the patients. Calcium channels and transporters can mediate Ca2+ balance inside and outside of the membrane, indicating that they may be closely related to the prognosis of MM. Therefore, this review focuses on the roles of some critical calcium channels and transporters in MM prognosis, which located in the plasma membrane, endoplasmic reticulum and mitochondria. The goal of this review is to facilitate the identification of new targets for the treatment and prognosis of MM.

中文翻译：

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钙通道和转运蛋白在多发性骨髓瘤中的病理生理作用

多发性骨髓瘤（MM）是一种常见的浆细胞恶性肿瘤。尽管在过去的二十年中采用了多种治疗方法，MM 仍然是一种侵袭性和无法治愈的疾病，迫切需要新的治疗策略。大约 70%～80% 的 MM 患者患有骨髓瘤骨病（MBD），常伴有病理性骨折和高钙血症，严重影响患者的预后。钙通道和转运蛋白可介导膜内外Ca2+平衡，提示其可能与MM的预后密切相关。因此，本综述重点关注位于质膜、内质网和线粒体中的一些关键钙通道和转运蛋白在MM预后中的作用。