The rs9953490 polymorphism of DAL-1 gene is associated with gastric cancer risk in the Han population in Northeast China,BMC Gastroenterology

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The rs9953490 polymorphism of DAL-1 gene is associated with gastric cancer risk in the Han population in Northeast China
BMC Gastroenterology ( IF 2.5 ) Pub Date : 2021-09-27 , DOI: 10.1186/s12876-021-01929-9
Hui Wang _{1,

2} , Yuling Jiang _{1,

3} , Lina Yu ₁ , Lidan Xu ₄ , Rongwei Guan ₄ , Mengdi Cai ₄ , Kexian Dong ₄ , Xiao Liang ₄ , Jing Bai ₄ , Jingcui Yu _{1,

4}

Affiliation

DAL-1 gene was reported to inhibit proliferation, migration, invasion, and epithelial to mesenchymal transition (EMT) of gastric cancer (GC) cells in our previous study. The association between the genomic variants in DAL-1 gene with risk of GC is still unclear. In this study, 505 GC cases and 544 healthy controls (HCs) were collected to evaluate the association between six single nucleotide polymorphisms (SNPs) (rs7240736, rs73937194, rs3817466, rs8082898, rs73381527, rs9953490) of DAL-1 gene and GC risk in the Han population in Northeast China. The TA + AA genotypes of rs9953490 were significantly associated with an increased risk in N3 compared with N0 subgroup (adjusted OR = 4.56, 95% CI = 1.49–13.98, P = 0.008), and also showed evident association with an increased risk in TNM stage III compared with stage I-II (adjusted OR = 2.33, 95% CI = 1.16–4.67, P = 0.017). The rs9953490 of DAL-1 gene may play an important role in the occurrence and development of GC in the Han population in Northeast China.

更新日期：2021-09-28

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