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Embryogenesis without CTCF in flies and vertebrates
Nature Structural & Molecular Biology ( IF 16.8 ) Pub Date : 2021-09-27 , DOI: 10.1038/s41594-021-00662-x
Geoffrey Fudenberg 1 , Elphège P Nora 2
Affiliation  

CTCF is a conserved DNA- and RNA-binding protein with roles in genome folding and transcriptional regulation. Two recent studies investigated how CTCF knockout perturbs genome biology and derails embryogenesis in zebrafish and Drosophila melanogaster, revealing contrasting effects across species.

中文翻译:

果蝇和脊椎动物无 CTCF 的胚胎发生

CTCF 是一种保守的 DNA 和 RNA 结合蛋白,在基因组折叠和转录调控中发挥作用。最近的两项研究调查了 CTCF 敲除如何扰乱斑马鱼和黑腹果蝇的基因组生物学和胚胎发生,揭示了不同物种的对比效应。
更新日期:2021-09-28
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