A new paper reports that the protein isthmin 1 is secreted by mature adipocytes and triggers a signalling cascade similar to that of insulin. The novel adipokine acts through an unidentified receptor tyrosine kinase and, at pharmacological doses in mice, isthmin 1 ameliorates metabolic disturbances associated with type 2 diabetes mellitus, including hyperglycaemia and liver steatosis.

中文翻译：

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Isthmin 1 — 一种新型胰岛素样脂肪因子

一篇新论文报道，蛋白质 isthmin 1 由成熟的脂肪细胞分泌，并触发类似于胰岛素的信号级联。这种新型脂肪因子通过一种未知的受体酪氨酸激酶发挥作用，并且在小鼠的药理剂量下，isthmin 1 可改善与 2 型糖尿病相关的代谢紊乱，包括高血糖症和肝脏脂肪变性。