Tanning, or increased epidermal pigmentation, protects organisms from ultraviolet radiation (UV)-induced damages. In this issue of Development Cell, Li et al. demonstrate a key role for a chromatin regulator—the Polycomb complex—in epidermal stem cells (EpSCs) in mediating UV-induced tanning responses and epidermal pigmentation.

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阳光下的表观遗传功能

晒黑或增加表皮色素沉着可保护生物体免受紫外线辐射 (UV) 引起的损害。在本期Development Cell 中，Li 等人。证明了染色质调节剂——Polycomb 复合物——在表皮干细胞 (EpSCs) 中在介导紫外线诱导的晒黑反应和表皮色素沉着方面的关键作用。