AMP-activated protein kinase (AMPK) is recognized as a critical regulator of cellular energy metabolism impacted by AMP/ATP and ADP/ATP ratios, or glucose- and fatty acid-derived metabolites. However, its ability to sense alterations in amino acid levels is poorly understood. Recent work by Yuan et al (2021) identifies a novel mechanism of AMPK regulation responsive to changes in availability of the sulfur-containing amino acid cysteine.

中文翻译：

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AMPK CA(R)Sts 为氨基酸传感带来新的曙光

AMP 活化蛋白激酶 (AMPK) 被认为是受 AMP/ATP 和 ADP/ATP 比率或葡萄糖和脂肪酸衍生代谢物影响的细胞能量代谢的关键调节剂。然而，人们对其感知氨基酸水平变化的能力知之甚少。Yuan等人(2021) 最近的工作确定了一种新的 AMPK 调节机制，该机制响应于含硫氨基酸半胱氨酸的可用性变化。