Since 2005, campylobacteriosis has been the most common zoonotic disease in Europe. The main reservoir of pathogenic Campylobacter strains is broilers, which makes raw and undercooked poultry meat two major sources of disease. Infection in chicken flocks is most often asymptomatic, despite a high level of colonization reaching 10⁶–10⁹cfu/g in animal ceca. It is widely believed that controlling the level of colonization of the birds’ digestive tract by pathogenic strains is a good way to increase food safety. Many treatments have been proposed to combat or at least reduce the level of colonization in animals reservoirs: probiotics, bacteriophages, vaccines, and anti-Campylobacter bacteriocins. This review focuses on the effects of Campylobacter infection on the chicken microbiome and colonization control strategies using probiotics (mostly lactic acid bacteria, LAB), which are live microorganisms included in the diet of animals as feed additives or supplements. Probiotics are not only an alternative to antibiotics, which were used for years as animal growth promoters, but they also constitute an effective protective barrier against excessive colonization of the digestive system by pathogenic bacteria, including Campylobacter. Moreover, one of the many beneficial functions of probiotics is the ability to manipulate the host’s microbiota. Recently, there have also been some promising attempts to use lactic acid bacteria as a delivery system of oral vaccine against Campylobacter. Recombinant LAB strains induce primarily a mucosal immune response against foreign antigens, accompanied by at most a low-level immune response against carrier strains. Since the main barrier against the invasion of pathogens in the gastrointestinal tract is the intestinal mucosal membrane, the development of effective oral vaccines to protect animals against enteric infection is very reasonable.

自 2005 年以来，弯曲杆菌病一直是欧洲最常见的人畜共患疾病。病原体的主要储存库弯曲杆菌菌株是肉鸡，这使得生的和未煮熟的家禽肉成为疾病的两个主要来源。尽管在动物盲肠中的定植水平高达 10 ⁶ –10 ⁹ cfu/g ，但鸡群中的感染通常是无症状的。人们普遍认为，控制病原菌对鸟类消化道的定植水平是提高食品安全的好方法。已经提出了许多治疗方法来对抗或至少降低动物宿主中的定植水平：益生菌、噬菌体、疫苗和抗弯曲杆菌细菌素。本综述重点关注弯曲杆菌使用益生菌（主要是乳酸菌，LAB）来控制鸡微生物群的感染和定植控制策略，益生菌是动物饮食中作为饲料添加剂或补充剂包含的活微生物。益生菌不仅是多年来一直用作动物生长促进剂的抗生素的替代品，而且还构成了有效的保护屏障，防止病原菌在消化系统中过度定植，包括弯曲杆菌. 此外，益生菌的众多有益功能之一是能够操纵宿主的微生物群。最近，也有一些有希望的尝试使用乳酸菌作为口服疫苗的传递系统。弯曲杆菌. 重组 LAB 菌株主要诱导针对外来抗原的粘膜免疫反应，最多伴有针对载体菌株的低水平免疫反应。由于胃肠道中抵抗病原体入侵的主要屏障是肠粘膜，因此开发有效的口服疫苗来保护动物免受肠道感染是非常合理的。