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An Unexpected Incident during the Manufacture of O-(Diphenylphosphinyl)hydroxylamine
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2021-09-28 , DOI: 10.1021/acs.oprd.1c00207 Curtis J. Rieder 1 , Mark V. Smith 1
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2021-09-28 , DOI: 10.1021/acs.oprd.1c00207 Curtis J. Rieder 1 , Mark V. Smith 1
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Scaling up processes to the manufacturing setting demands vigilance, even with controls implemented to mitigate potential thermal hazards. This was highlighted when an unexpected thermal decomposition of O-(diphenylphosphinyl)hydroxylamine (DPPH) occurred during its isolation on scale using an agitated pressure filter/dryer. The decomposition propagated outside of the confines of the filter and glovebox used for discharging, resulting in the further decomposition of previously discharged DPPH contained in a bag below the glovebox. The investigation of the incident confirmed that after initiation, the thermal decomposition of DPPH could propagate through the manufacturing equipment. Although the cause of the initial decomposition could not be definitively ascribed, it was most likely the result of an electrostatic discharge during heel removal from the filter.
中文翻译：
O-(二苯基膦基)羟胺生产过程中的一起意外事件
将流程扩展到制造环境需要保持警惕，即使实施控制措施以减轻潜在的热危害。当O的意外热分解时突出显示了这一点-（二苯基膦基）羟胺 (DPPH) 在使用搅拌压力过滤器/干燥器进行大规模分离期间发生。分解传播到用于排放的过滤器和手套箱的范围之外，导致手套箱下方袋子中先前排放的 DPPH 进一步分解。对事件的调查证实，DPPH 的热分解可以在引发后通过制造设备传播。虽然无法确定最初分解的原因，但很可能是从过滤器中取出后部时静电放电的结果。
更新日期：2021-10-15
中文翻译：
O-(二苯基膦基)羟胺生产过程中的一起意外事件
将流程扩展到制造环境需要保持警惕，即使实施控制措施以减轻潜在的热危害。当O的意外热分解时突出显示了这一点-（二苯基膦基）羟胺 (DPPH) 在使用搅拌压力过滤器/干燥器进行大规模分离期间发生。分解传播到用于排放的过滤器和手套箱的范围之外，导致手套箱下方袋子中先前排放的 DPPH 进一步分解。对事件的调查证实，DPPH 的热分解可以在引发后通过制造设备传播。虽然无法确定最初分解的原因，但很可能是从过滤器中取出后部时静电放电的结果。
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