Potential long-term effect of tumor necrosis factor inhibitors on dementia risk: A propensity score matched retrospective cohort study in US veterans,Alzheimer's & Dementia

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Potential long-term effect of tumor necrosis factor inhibitors on dementia risk: A propensity score matched retrospective cohort study in US veterans
Alzheimer's & Dementia ( IF 13.0 ) Pub Date : 2021-09-27 , DOI: 10.1002/alz.12465
Chunlei Zheng _{1,

2} , Nathanael R Fillmore _{2,

3,

4} , Jaime Ramos-Cejudo _{2,

5} , Mary Brophy _{2,

6} , Ricardo Osorio _{7,

8} , Mark E Gurney ₉ , Wei Qiao Qiu _{10,

11,

12} , Rhoda Au _{13,

14} , George Perry ₁₅ , Maureen Dubreuil _{2,

6} , Shu G Chen ₁₆ , Xin Qi ₁₇ , Pamela B Davis ₁₈ , Nhan Do _{2,

6} , Rong Xu _{1,

19}

Affiliation

Center for Artificial Intelligence in Drug Discovery, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
VA Boston Cooperative Studies Program, MAVERIC, VA Boston Healthcare System, Boston, Massachusetts, USA.
Harvard Medical School, Boston, Massachusetts, USA.
Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Division of Brain Aging, Department of Psychiatry, New York University School of Medicine, New York City, New York, USA.
Boston University School of Medicine, Boston, Massachusetts, USA.
Department of Psychiatry, Healthy Brain Aging and Sleep Center, NYU Langone Medical Center, New York, New York, USA.
Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York, New York, USA.
Tetra Therapeutics, Grand Rapids, Michigan, USA.
Department of Pharmacology and Experimental Therapeutics, Boston University Medical Campus, Boston, Massachusetts, USA.
Alzheimer's Disease Center, Boston University Medical Campus, Boston, Massachusetts, USA.
Department of Psychiatry, Boston University Medical Campus, Boston, Massachusetts, USA.
Department of Anatomy & Neurobiology, Boston University School of Medicine, Boston, Massachusetts, USA.
Boston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
College of Sciences, The University of Texas at San Antonio, San Antonio, Texas, USA.
Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Department of Physiology & Biophysics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Center for Clinical Investigation, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA.

Tumor necrosis factor (TNF) inhibitors are widely used to treat rheumatoid arthritis (RA) and their potential to retard Alzheimer's disease (AD) progression has been reported. However, their long-term effects on the dementia/AD risk remain unknown.

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