OBJECTIVE Deep brain stimulation (DBS) in Parkinson's disease (PD) is associated with an increased risk of post-operative cognitive deterioration. Preoperative neuropsychological testing can be affected and limited by the patient's collaboration in advanced disease. The purpose of this study was to determine whether preoperative quantitative electroencephalography (qEEG) may be a useful complementary examination technique during preoperative assessment to predict cognitive changes in PD patients treated with DBS. METHODS We compared the cognitive performance of 16 PD patients who underwent bilateral subthalamic nucleus DBS to the performance of 15 PD controls (matched for age, sex, and education) at baseline and at 24 months. Cognitive scores were calculated for all patients across 5 domains. A preoperative 256-channel resting EEG was recorded from each patient. We computed the global relative power spectra. Correlation and linear regression models were used to assess associations of preoperative EEG measures with post-operative cognitive scores. RESULTS Slow waves (relative delta and theta band power) were negatively correlated with post-operative cognitive performance, while faster waves (alpha 1) were strongly positively correlated with the same scores (the overall cognitive score, attention, and executive function). Linear models revealed an association of delta power with the overall cognitive score (p = 0.00409, adjusted R2 = 0.6341). Verbal fluency (VF) showed a significant decline after DBS surgery, which was correlated with qEEG measures. CONCLUSIONS To analyse the side effects after DBS in PD patients, the most important parameter is verbal fluency capacity. In addition, correlation with EEG frequency bands might be useful to detect particularly vulnerable patients for cognitive impairment and be supportive in the selection process of patients considered for DBS.

中文翻译：

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定量脑电图是否可以改善接受深部脑刺激治疗的帕金森病患者的术前认知评估？后续研究。

目的 帕金森病 (PD) 中的深部脑刺激 (DBS) 与术后认知功能恶化的风险增加有关。术前神经心理测试可能会受到患者在晚期疾病中的合作的影响和限制。本研究的目的是确定术前定量脑电图 (qEEG) 是否可以作为术前评估期间有用的补充检查技术，以预测 DBS 治疗的 PD 患者的认知变化。方法 我们比较了 16 名接受双侧丘脑底核 DBS 的 PD 患者与 15 名 PD 对照组（年龄、性别和教育程度匹配）在基线和 24 个月时的认知表现。计算所有患者的认知评分跨越 5 个领域。记录每位患者的术前 256 通道静息脑电图。我们计算了全局相对功率谱。相关性和线性回归模型用于评估术前脑电图测量与术后认知评分的关联。结果 慢波（相对 delta 和 theta 波段功率）与术后认知能力呈负相关，而快波（alpha 1）与相同分数（总体认知分数、注意力和执行功能）呈强正相关。线性模型揭示了 delta power 与整体认知评分的关联（p = 0.00409，调整后的 R2 = 0.6341）。DBS 手术后言语流畅度 (VF) 显着下降，这与 qEEG 测量相关。结论 为了分析 PD 患者 DBS 后的副作用，最重要的参数是语言流利能力。此外，与 EEG 频带的相关性可能有助于检测特别易患认知障碍的患者，并在考虑进行 DBS 的患者选择过程中提供支持。