PURPOSE To explore the predictive value of and the relationship between the gamma-glutamyl transpeptidase (GGT) to lymphocyte ratio (GLR) and computed tomography (CT) features in hepatocellular carcinoma (HCC) patients with postoperative adjuvant transarterial chemoembolization (PA-TACE). METHODS Between January 2012 and June 2015, 150 HCC patients who underwent adjuvant TACE after hepatectomy in the Affiliated Hospital of Nantong University were selected. Baseline parameters, laboratory values, clinical variables, and CT features (including CT values, irregular rim-like arterial phase enhancement (IRE), and CT enhanced values) were evaluated in all of the patients. The Mann-Whitney U test was performed to assess the GLR values between the patients with microvascular invasion (MVI) and those without MVI. Spearman correlation analysis was performed to evaluate the relationship between IRE and GLR. A nomogram based on the multivariate analysis was constructed. RESULTS Using multivariate analysis, GLR, MVI, α-fetoprotein levels, and IRE were found to be independent prognostic factors for overall survival (OS). In the MVI group, the GLR of patients was higher than that in the non-MVI group (z=-6.652, p<0.001). We observed a clear correlation between GLR and IRE (r=0.522, p<0.001). The nomogram was constructed and the calibration curve showed excellent predictive performance. CONCLUSIONS We observed a correlation between GLR and CT features in HCC patients. The nomogram based on clinical data, pathological data, and CT features was suggested to predict the 5-year survival of HCC patients with PA-TACE, which offers an accurate, comprehensive, and reliable evaluation for individualized treatment.

中文翻译：

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γ-谷氨酰转肽酶与淋巴细胞比值与肝细胞癌术后辅助 TACE 患者 CT 特征的预测价值及关系。

目的 探讨 γ-谷氨酰转肽酶 (GGT) 与淋巴细胞比值 (GLR) 和计算机断层扫描 (CT) 特征在肝细胞癌 (HCC) 患者术后辅助经动脉化疗栓塞 (PA-TACE) 中的预测价值和关系。方法选择2012年1月至2015年6月在南通大学附属医院接受肝切除术后辅助TACE的HCC患者150例。评估所有患者的基线参数、实验室值、临床变量和 CT 特征（包括 CT 值、不规则轮缘状动脉期增强 (IRE) 和 CT 增强值）。进行 Mann-Whitney U 检验以评估有微血管侵犯 (MVI) 的患者和没有 MVI 的患者之间的 GLR 值。进行Spearman相关分析以评估IRE和GLR之间的关系。构建了基于多变量分析的列线图。结果 使用多变量分析，发现 GLR、MVI、甲胎蛋白水平和 IRE 是总生存期 (OS) 的独立预后因素。MVI组患者的GLR高于非MVI组（z=-6.652，p<0.001）。我们观察到 GLR 和 IRE 之间存在明显的相关性（r=0.522，p<0.001）。构建了列线图，校准曲线显示了出色的预测性能。结论 我们观察到 HCC 患者的 GLR 和 CT 特征之间存在相关性。提出基于临床数据、病理数据和 CT 特征的列线图预测 HCC 患者 PA-TACE 的 5 年生存率，提供准确、全面、