The genetic background and the antigenic landscape of cancer cells play a critical role in the response to immunotherapies. A high tumor antigenicity, together with an increased adjuvanticity potentially induced by a peculiar type of cell death, namely immunogenic cell death (ICD), could foster the response to immunogenic therapies. The gestational trophoblastic neoplasm (GTN) is a one-of-a-kind cancer in the oncological landscape due to its exclusive genomic makeup. The prognosis of GTN is significantly better than non-gestational trophoblastic neoplasm (nGTN). Due to its peculiar genetic inheritance, GTN potentially constitutes a singular archetype in the immuno-oncological field.

癌细胞的遗传背景和抗原景观在对免疫疗法的反应中起着关键作用。高肿瘤抗原性以及可能由特殊类型的细胞死亡，即免疫原性细胞死亡 (ICD) 诱导的佐剂性增加，可以促进对免疫原性治疗的反应。由于其独特的基因组构成，妊娠滋养细胞肿瘤 (GTN) 是肿瘤学领域中一种独一无二的癌症。GTN的预后明显优于非妊娠滋养细胞肿瘤（nGTN）。由于其独特的遗传遗传，GTN 可能构成免疫肿瘤学领域的单一原型。