Magnetic Fe3O4@graphene oxide improves the therapeutic effects of embryonic stem cells on acute liver damage,Cell Proliferation

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Magnetic Fe3O4@graphene oxide improves the therapeutic effects of embryonic stem cells on acute liver damage
Cell Proliferation ( IF 5.9 ) Pub Date : 2021-09-27 , DOI: 10.1111/cpr.13126
Tahereh Foroutan ₁ , Mohammad Zaman Kassaee ₂ , Mahdi Salari ₃ , Fatemeh Ahmady ₁ , Fatemeh Molavi ₁ , Fariborz Moayer ₄

Affiliation

Acute liver failure is usually associated with inflammation and oxidation of hepatocytes and has high mortality and resource costs. Mesenchymal stem cell (MSCs) has occasionally been reported to have no beneficial effect due to poor transplantation and the survival of implanted cells. Recent studies showed that embryonic stem cell (ESC)-derived MSCs are an alternative for regenerative medicine. On the other hand, graphene-based nanostructures have proven useful in biomedicine. In this study, we investigated whether magnetic graphene oxide (MGO) improved the effects of ESC-MSC conditioned medium (CM) on protecting hepatocytes and stimulating the regeneration of damaged liver cells.

中文翻译：

磁性Fe3O4@氧化石墨烯提高胚胎干细胞对急性肝损伤的治疗效果

急性肝衰竭通常与肝细胞炎症和氧化有关，死亡率和资源成本很高。偶尔有报道称间充质干细胞（MSC）由于移植效果不佳和植入细胞的存活而没有任何有益效果。最近的研究表明，胚胎干细胞 (ESC) 衍生的间充质干细胞是再生医学的替代品。另一方面，基于石墨烯的纳米结构已被证明可用于生物医学。在本研究中，我们研究了磁性氧化石墨烯（MGO）是否可以改善ESC-MSC条件培养基（CM）保护肝细胞和刺激受损肝细胞再生的效果。

更新日期：2021-11-03

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