IgM and IgA augmented autoantibody signatures improve early-stage detection of colorectal cancer prior to nodal and distant spread,Clinical & Translational Immunology

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IgM and IgA augmented autoantibody signatures improve early-stage detection of colorectal cancer prior to nodal and distant spread
Clinical & Translational Immunology ( IF 4.6 ) Pub Date : 2021-09-26 , DOI: 10.1002/cti2.1330
Md Saiful Islam Roney ₁ , Catharine Lanagan ₁ , Yong Hua Sheng ₂ , Karen Lawler ₃ , Christopher Schmidt ₁ , Nam-Trung Nguyen ₄ , Jakob Begun _{2,

5} , Gregor Stefan Kijanka _{1,

4}

Affiliation

Tumor-associated autoantibodies (AAbs) in individuals with cancer can precede clinical diagnosis by several months to years. The objective of this study was to determine whether the primary immune response in form of IgM and gut mucosa-associated IgA can aid IgG AAbs in the detection of early-stage colorectal cancer (CRC).

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