Molecular engineering of organic-based agents for in situ bioimaging and phototherapeutics,Chemical Society Reviews

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Molecular engineering of organic-based agents for in situ bioimaging and phototherapeutics
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2021-09-27 , DOI: 10.1039/d1cs00408e
Ke Li ₁ , Shuai Xu ₁ , Mengyi Xiong ₁ , Shuang-Yan Huan ₁ , Lin Yuan ₁ , Xiao-Bing Zhang ₁

Affiliation

In situ monitoring of the location and transportation of bioactive molecules is essential for deciphering diverse biological events in the field of biomedicine. In addition, obtaining the in situ information of lesions will provide a clear perspective for surgeons to perform precise resection in clinical surgery. Notably, delivering drugs or operating photodynamic therapy/photothermal therapy in situ by labeling the lesion regions of interest can improve treatment and reduce side effects in vivo. In various advanced imaging and therapy modalities, optical theranostic agents based on organic small molecules can be conveniently modified as needed and can be easily internalized into cells/lesions in a non-invasive manner, which are prerequisites for in situ bioimaging and precision treatment. In this tutorial review, we first summarize the in situ molecular immobilization strategies to retain small-molecule agents inside cells/lesions to prevent their diffusion in living organisms. Emphasis will be focused on introducing the application of these strategies for in situ imaging of biomolecules and precision treatment, particularly pertaining to why targeting therapy in situ is required.

中文翻译：

用于原位生物成像和光疗的有机基试剂的分子工程

生物活性分子的位置和运输的原位监测对于破译生物医学领域的各种生物事件至关重要。此外，获得病灶的原位信息将为外科医生在临床手术中进行精确切除提供清晰的视角。值得注意的是，通过标记感兴趣的病变区域来原位递送药物或操作光动力疗法/光热疗法可以改善治疗并减少体内副作用. 在各种先进的成像和治疗方式中，基于有机小分子的光学治疗剂可以根据需要方便地进行修改，并且可以以非侵入性的方式轻松地内化到细胞/病变中，这是原位生物成像和精准治疗的先决条件。在本教程回顾中，我们首先总结了原位分子固定化策略，以将小分子药物保留在细胞/病变内，以防止它们在生物体中扩散。重点将集中在介绍这些策略在生物分子原位成像和精准治疗中的应用，特别是关于为什么需要原位靶向治疗。

更新日期：2021-09-27

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