In solution, a prebiotically plausible ribozyme formed from short oligonucleotides reversibly cleaves an RNA substrate. However, in the presence of poly-L-lysine, phase separation occurs owing to charge interactions between the oppositely charged RNA and peptide. The resulting compartments greatly enhance ribozyme activity, driving the reaction equilibrium towards the ligation of long and complex RNA in mild conditions.

中文翻译：

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肽-RNA缩合物中增强的核酶催化重组和寡核苷酸组装

在溶液中，由短寡核苷酸形成的益生元核酶可逆地切割 RNA 底物。然而，在多聚-L-赖氨酸存在的情况下，由于带相反电荷的 RNA 和肽之间的电荷相互作用而发生相分离。由此产生的隔室极大地增强了核酶活性，推动反应平衡朝着在温和条件下连接长而复杂的 RNA 的方向发展。