Why obstructive sleep apnea (OSA) treatment does not completely restore healthy metabolic physiology is unclear. In rats, the need for respiratory homeostasis maintenance following airway obstruction (AO) is associated with a loss of thermoregulation and abnormal metabolic physiology that persists following successful obstruction removal. Here, we explored the effect of two different types of tracheal narrowing, i.e., AO and mild airway obstruction (mAO), and its removal on respiratory homeostasis and metabolic physiology. We show that after ten weeks, mAO vs. AO consumes sufficient energy that is required to maintain respiratory homeostasis and thermoregulation. Obstruction removal was associated with largely irreversible increased feeding associated with elevated serum ghrelin, hypothalamic growth hormone secretagogue receptor 1a, and a phosphorylated Akt/Akt ratio, despite normalization of breathing and energy requirements. Our study supports the need for lifestyle eating behavior management, in addition to endocrine support, in order to attain healthy metabolic physiology in OSA patients.

为什么阻塞性睡眠呼吸暂停 (OSA) 治疗不能完全恢复健康的代谢生理机能尚不清楚。在大鼠中，气道阻塞（AO）后维持呼吸稳态的需要与体温调节丧失和代谢生理学异常有关，这些现象在成功清除阻塞后仍然存在。在这里，我们探讨了两种不同类型的气管狭窄，即 AO 和轻度气道阻塞 (mAO) 的影响，及其去除对呼吸稳态和代谢生理学的影响。我们发现，十周后，mAO 与 AO 消耗了维持呼吸稳态和体温调节所需的足够能量。尽管呼吸和能量需求正常化，但阻塞去除与血清生长素释放肽、下丘脑生长激素促分泌素受体 1a 升高和磷酸化 Akt/Akt 比率相关的摄食量增加在很大程度上是不可逆的。我们的研究支持除了内分泌支持之外还需要生活方式饮食行为管理，以便 OSA 患者获得健康的代谢生理学。