Endometriosis is a chronic inflammatory disease which increasingly affects young women under 35 years of age and leads to subfertility even infertility. Analysis of the cytotoxic effect of zinc(II) niflumato complex with neocuproine ([Zn(neo)(nif)₂] or Zn-Nif) on immortalized human endometriotic cell line (12Z) and on control immortalized human endometrial stromal cell line (hTERT) was performed using xCELLigence technology for approximately 72 h following the treatment with Zn-Nif as well as cell viability Trypan Blue Assay. 12Z cell line proliferated more slowly compared to unaffected cells, whereas hTERT cells did not show similar behavior after treatment. The complex probably reduces the effect of pro-inflammatory pathways due to the effect of NSAID, while presence of zinc might reduce the level of ROS and regulate ER2 levels and MMP activity. The observed effects and high selectivity for rapidly proliferating cells with increased inflammatory activity suggest a good prognosis of successful decrease of endometriosis stage with this complex.

子宫内膜异位症是一种慢性炎症性疾病，越来越多地影响35岁以下的年轻女性，并导致生育力低下甚至不孕。锌(II)尼氟马托与新铜灵复合物([Zn( neo )( nif ) ₂ ]或Zn-Nif)对永生化人子宫内膜异位细胞系(12Z)和对照永生化人子宫内膜基质细胞系(hTERT)的细胞毒性作用分析）是在用 Zn-Nif 处理后使用 xCELLigence 技术进行约 72 小时以及细胞活力台盼蓝测定。与未受影响的细胞相比，12Z 细胞系增殖更慢，而 hTERT 细胞在治疗后没有表现出类似的行为。由于 NSAID 的作用，该复合物可能会降低促炎途径的影响，而锌的存在可能会降低 ROS 水平并调节 ER2 水平和 MMP 活性。观察到的效果和对炎症活性增加的快速增殖细胞的高选择性表明，使用该复合物成功降低子宫内膜异位症阶段的良好预后。