Katalin Karikó describes the discovery that replacing uridine with pseudouridine renders RNA non-immunogenic. This paved the way for developing mRNA for protein replacement therapy and, surprisingly, also for mRNA-based vaccine development.

中文翻译：

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修饰的尿苷是成功传递信息的关键

Katalin Karikó 描述了用假尿苷替代尿苷可使 RNA 不具有免疫原性的发现。这为开发用于蛋白质替代疗法的 mRNA 铺平了道路，令人惊讶的是，也为基于 mRNA 的疫苗开发铺平了道路。