Global Incidence of Acute Pancreatitis Is Increasing Over Time: A Systematic Review and Meta-Analysis,Gastroenterology

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Global Incidence of Acute Pancreatitis Is Increasing Over Time: A Systematic Review and Meta-Analysis
Gastroenterology ( IF 25.7 ) Pub Date : 2021-09-25 , DOI: 10.1053/j.gastro.2021.09.043
Jordan P Iannuzzi ₁ , James A King ₁ , Jessica Hope Leong ₁ , Joshua Quan ₁ , Joseph W Windsor ₂ , Divine Tanyingoh ₃ , Stephanie Coward ₃ , Nauzer Forbes ₂ , Steven J Heitman ₃ , Abdel-Aziz Shaheen ₃ , Mark Swain ₂ , Michael Buie ₁ , Fox E Underwood ₃ , Gilaad G Kaplan ₃

Affiliation

Background & Aims

Acute pancreatitis is a common disease with significant associated morbidity and mortality. We performed a systematic review and meta-analysis of population-based studies to explore the changing temporal trends of acute pancreatitis incidence globally.

Methods

We performed a systematic literature search to identify population-based studies reporting the annual incidence of acute pancreatitis. Abstracts were assessed independently to identify applicable articles for full-text review and data extraction. Joinpoint temporal trend analyses were performed to calculate the average annual percent change (AAPC) with 95% confidence intervals (CIs). The AAPCs were pooled in a meta-analysis to capture the overall and regional trends in acute pancreatitis incidence over time. Temporal data were summarized in a static map and an interactive, web-based map.

Results

Forty-four studies reported the temporal incidence of acute pancreatitis (online interactive map: https://kaplan-acute-pancreatitis-ucalgary.hub.arcgis.com/). The incidence of acute pancreatitis has increased from 1961 to 2016 (AAPC, 3.07%; 95% CI, 2.30% to 3.84%; n = 34). Increasing incidence was observed in North America (AAPC, 3.67%; 95% CI, 2.76% to 4.57%; n = 4) and Europe (AAPC, 2.77%; 95% CI, 1.91% to 3.63%; n = 23). The incidence of acute pancreatitis was stable in Asia (AAPC, –0.28%; 95% CI, –5.03% to 4.47%; n = 4).

Conclusions

This meta-analysis provides a comprehensive overview of the global incidence of acute pancreatitis over the last 56 years and demonstrates a steadily rising incidence over time in most countries of the Western world. More studies are needed to better define the changing incidence of acute pancreatitis in Asia, Africa, and Latin America.

中文翻译：

全球急性胰腺炎发病率随着时间的推移而增加：系统回顾和荟萃分析

背景与目标

急性胰腺炎是一种具有显着相关发病率和死亡率的常见疾病。我们对基于人群的研究进行了系统回顾和荟萃分析，以探索全球急性胰腺炎发病率变化的时间趋势。

方法

我们进行了系统的文献检索，以确定报告急性胰腺炎年发病率的基于人群的研究。对摘要进行独立评估，以确定适用于全文审查和数据提取的文章。进行连接点时间趋势分析以计算具有 95% 置信区间 (CI) 的平均年百分比变化 (AAPC)。将 AAPC 汇总在一项荟萃分析中，以捕捉急性胰腺炎发病率随时间推移的总体和区域趋势。时间数据汇总在一张静态地图和一张基于网络的交互式地图中。

结果

44 项研究报告了急性胰腺炎的时间发病率（在线互动地图：https://kaplan-acute-pancreatitis-ucalgary.hub.arcgis.com/）。从 1961 年到 2016 年，急性胰腺炎的发病率有所增加（AAPC，3.07%；95% CI，2.30% 到 3.84%；n = 34）。在北美（AAPC，3.67%；95% CI，2.76% 至 4.57%；n = 4）和欧洲（AAPC，2.77%；95% CI，1.91% 至 3.63%；n = 23）观察到发病率增加。亚洲的急性胰腺炎发病率稳定（AAPC，–0.28%；95% CI，–5.03% 至 4.47%；n = 4）。