microRNA (miRNA) molecules are considered as biomarkers and have promising future for early-stage cancer diagnosis. Lawsone (Law) enriched carbon nanofibers (CNFs) were prepared via electrospinning process for the selective miRNA detection. Anti-miRNA molecules were attached on the CNFs immobilized screen printed electrodes (SPE) and used for the detection of miRNA molecules by observing guanine oxidation signal via differential pulse voltammetry (DPV) method. Three different miRNA molecules including the target (miRNA), single-base mismatched (SM.miRNA) and non-complementary (NC.miRNA) were hybridized with the previously attached anti-miRNA molecules (with guanine [PolyT(G)] and without guanine [PolyT(I)]) on the CNFs immobilized SPE surfaces.

中文翻译：

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Lawsone辅助制备用于选择性检测miRNA分子的碳纳米纤维

microRNA (miRNA) 分子被认为是生物标志物，在早期癌症诊断中具有广阔的前景。通过静电纺丝工艺制备了富含劳森 (Law) 的碳纳米纤维 (CNF)，用于选择性 miRNA 检测。抗miRNA分子附着在CNFs固定的丝网印刷电极（SPE）上，用于通过差分脉冲伏安法（DPV）观察鸟嘌呤氧化信号来检测miRNA分子。三种不同的 miRNA 分子，包括靶标 (miRNA)、单碱基错配 (SM.miRNA) 和非互补 (NC.miRNA) 与先前连接的抗 miRNA 分子（含鸟嘌呤 [PolyT(G)] 和不含鸟嘌呤 [PolyT(G)] CNFs 固定的 SPE 表面上的鸟嘌呤 [PolyT(I)])。