D-mannose alleviates osteoarthritis progression by inhibiting chondrocyte ferroptosis in a HIF-2α-dependent manner,Cell Proliferation

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D-mannose alleviates osteoarthritis progression by inhibiting chondrocyte ferroptosis in a HIF-2α-dependent manner
Cell Proliferation ( IF 5.9 ) Pub Date : 2021-09-25 , DOI: 10.1111/cpr.13134
Xueman Zhou _{1,

2} , Yingcheng Zheng _{1,

2} , Wentian Sun _{1,

2} , Zhenzhen Zhang _{1,

2} , Jiaqi Liu _{1,

2} , Wenke Yang _{1,

2} , Wenxiu Yuan _{1,

2} , Yating Yi ₁ , Jun Wang ₁ , Jin Liu ₂

Affiliation

Chondrocyte ferroptosis contributes to osteoarthritis (OA) progression, and D-mannose shows therapeutic value in many inflammatory conditions. Here, we investigated whether D-mannose interferes in chondrocyte ferroptotic cell death during osteoarthritic cartilage degeneration.

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