Fungi are ubiquitous in nature, and typically cause little or no environmental or pathogenic damage to their plant, animal, and human hosts. However, a small but growing number of pathogenic fungi are spreading world-wide at an alarming rate threatening global ecosystem health and proliferation. Many of these emerging pathogens have developed multi-drug resistance to front line therapeutics increasing the urgency for the development of new antifungal agents. This review examines the development of thiosemicarbazones, bis(thiosemicarbazones), and their metal complexes as potential antifungal agents against more than 65 different fungal strains. The fungistatic activity of the compounds are quantified based on the zone of inhibition, minimum inhibitory concentration, or growth inhibition percentage. In this review, reported activities were standardized based on molar concentrations to simplify comparisons between different compounds. Of all the fungal strains reported in the review, A. niger in particular was very resistant towards a majority of tested compounds. Our analysis of the data shows that metal complexes are typically more active than non-coordinated ligands with copper(II) and zinc(II) complexes generally displaying the highest activity.

真菌在自然界中无处不在，通常对其植物、动物和人类宿主几乎没有或不会造成环境或病原性损害。然而，少量但不断增长的病原真菌正以惊人的速度在世界范围内传播，威胁着全球生态系统的健康和增殖。许多这些新出现的病原体已经对一线治疗产生了多药耐药性，这增加了开发新抗真菌药物的紧迫性。本综述考察了氨基硫脲、双（氨基硫脲）及其金属配合物作为针对超过 65 种不同真菌菌株的潜在抗真菌剂的发展。基于抑制区、最小抑制浓度或生长抑制百分比来量化化合物的抑菌活性。在本次审查中，报告的活性是基于摩尔浓度标准化的，以简化不同化合物之间的比较。在审查报告的所有真菌菌株中，尤其是A. niger对大多数测试化合物具有很强的抵抗力。我们对数据的分析表明，金属配合物通常比非配位配体更具活性，而铜 (II) 和锌 (II) 配合物通常表现出最高的活性。