Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseases,Hepatology

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Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseases
Hepatology ( IF 12.9 ) Pub Date : 2021-09-26 , DOI: 10.1002/hep.32175
Hyun-Seok Kim _{1,

2,

3} , Silvia Sookoian _{4,

5} , Ruben Hernaez _{1,

2,

6}

Affiliation

Over the last decade, genome-wide association studies (GWAS) have allowed for the dissection of the genetic susceptibility to complex liver diseases.¹ In a recent issue of Nature communications, Chen and colleagues conducted a meta-analysis of GWAS collected in ~390,000 individuals of the UK BioBank and ~160,000 Japanese individuals from the BioBank Japan to expand the understanding of the genetic determinants of serum levels of liver-related enzymes.²

中文翻译：

肝脏相关酶的全基因组关联研究表明对多种性状和疾病的假定多效性

在过去十年中，全基因组关联研究 (GWAS) 允许剖析复杂肝病的遗传易感性。¹在最近一期《自然通讯》中，Chen 及其同事对在英国生物库的约 390,000 个人和日本生物银行的约 160,000 个人中收集的 GWAS 进行了荟萃分析，以扩大对肝脏血清水平的遗传决定因素的理解相关酶。²

更新日期：2021-09-27

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