Acute liver failure (ALF) is characterized by significant changes in the hemostatic system and by systemic inflammation. The formation of neutrophil extracellular traps (NETs), in which an activated neutrophil expels its DNA, histones, and granular enzymes, such as myeloperoxidase (MPO), has been associated with immune-mediated and thrombotic diseases. We hypothesized that formation of NETs in patients with ALF contributes to progression of disease.

中文翻译：

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急性肝衰竭患者中性粒细胞胞外陷阱的产生与不良预后相关

急性肝功能衰竭 (ALF) 的特征在于止血系统的显着变化和全身炎症。中性粒细胞胞外陷阱 (NETs) 的形成，其中活化的中性粒细胞排出其 DNA、组蛋白和粒状酶，如髓过氧化物酶 (MPO)，与免疫介导和血栓形成疾病有关。我们假设 ALF 患者中 NET 的形成有助于疾病的进展。