Objective

To characterize the differences and correlations in osteophyte volumes between and within proximal tibial compartments, and to assess the correlations between osteophyte volumes and the femorotibial angle.

Design

CT scans of 73 knees with predominantly medial femorotibial osteoarthritis (21 K/L2, 28 K/L3, 24 K/L4) were retrospectively analyzed using a new, reproducible method measuring total and subregional osteophyte volumes in the medial and lateral compartments. Non-parametric statistics was used for comparison and correlation analyses.

Results

Total osteophyte volumes were larger in the medial than in the lateral compartment for all severity groups (p < 0.05). Additionally, statistically significant differences were observed among subregions of the lateral compartment in K/L3 and K/L4 knees.

Statistically significant positive correlations were found between the medial and lateral total osteophyte volumes in K/L3 and K/L4 knees (ρ ≥ 0.44, p = 0.03), and among most subregional osteophyte volumes within each compartment in K/L3 knees. Markedly fewer statistically significant correlations were present in K/L2 and K/L4 knees.

In K/L3 knees, the femorotibial angle was statistically significantly positively correlated with the total osteophyte volume in the medial compartment (ρ = 0.50, p = 0.01), with osteophyte volumes in most medial subregions, and with the osteophyte volume in the lateral posterior subregion (ρ = 0.40, p = 0.05).

Conclusions

Quantitative assessment of osteophytes may bring insight on factors influencing their development. Positive correlations of osteophyte volumes found between and within compartments suggest the influence of biochemical mediators acting on the entire joint, while positive correlations between the femorotibial angle and osteophyte volumes suggest a role of mechanical factors. These hypotheses are to be further confirmed.

中文翻译：

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胫骨近端骨赘体积在空间上与膝关节对齐相关：定量分析表明生化和机械因素对骨赘发展的影响

客观的

表征胫骨近端隔室之间和内部骨赘体积的差异和相关性，并评估骨赘体积与股胫角之间的相关性。

设计

使用一种新的、可重复的方法测量内侧和外侧隔室的总和亚区域骨赘体积，回顾性分析了 73 例主要患有内侧股胫骨关节炎（21 K/L2、28 K/L3、24 K/L4）的膝关节的 CT 扫描。非参数统计用于比较和相关分析。

结果

对于所有严重程度组，内侧的总骨赘体积大于外侧隔室（p  < 0.05）。此外，在 K/L3 和 K/L4 膝关节外侧室的子区域之间观察到统计学上的显着差异。

在 K/L3 和 K/L4 膝关节的内侧和外侧总骨赘体积（ ρ  ≥ 0.44，p  = 0.03）之间，以及在 K/L3 膝关节每个隔室内的大多数次区域骨赘体积之间发现了统计学上显着的正相关。K/L2 和 K/L4 膝关节的统计学显着相关性显着减少。

在 K/L3 膝关节中，股胫角与内侧隔室的总骨赘体积（ ρ  = 0.50，p  = 0.01）、大多数内侧亚区域的骨赘体积以及外侧后部的骨赘体积呈显着正相关子区域 ( ρ  = 0.40, p  = 0.05)。

结论

骨赘的定量评估可能会带来影响其发展的因素的洞察力。在隔间之间和隔间内发现的骨赘体积的正相关表明生化介质作用于整个关节的影响，而股胫角和骨赘体积之间的正相关表明机械因素的作用。这些假设有待进一步证实。