Abstract

Despite extensive research, there is still no treatment that would lead to remission in all patients with rheumatoid arthritis as our understanding of the affected site, the synovium, is still incomplete. Recently, single-cell technologies helped to decipher the cellular heterogeneity of the synovium; however, certain synovial cell populations, such as endothelial cells or peripheral neurons, remain to be profiled on a single-cell level. Furthermore, associations between certain cellular states and inflammation were found; whether these cells cause the inflammation remains to be answered. Similarly, cellular zonation and interactions between individual effectors in the synovium are yet to be fully determined. A deeper understanding of cell signalling and interactions in the synovium is crucial for a better design of therapeutics with the goal of complete remission in all patients.

中文翻译：

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滑膜单细胞异质性、分区和相互作用：关节炎中效应器的拼凑

摘要

尽管进行了广泛的研究，但由于我们对受影响部位滑膜的了解仍然不完整，因此仍然没有可以使所有类风湿性关节炎患者缓解的治疗方法。最近，单细胞技术有助于破译滑膜的细胞异质性。然而，某些滑膜细胞群，如内皮细胞或外周神经元，仍有待在单细胞水平上进行分析。此外，还发现了某些细胞状态与炎症之间的关联；这些细胞是否引起炎症仍有待回答。同样，滑膜中单个效应器之间的细胞分区和相互作用尚未完全确定。