Adoptive cell therapy with T cells engineered with customized receptors that redirect antigen specificity to cancer cells has emerged as an effective therapeutic approach for many malignancies. Toxicity due to on target or off target effects, antigen heterogeneity on cancer cells, and acquired T cell dysfunction have been identified as barriers that can hinder successful therapy. This review will discuss recent advances in T cell engineering that have enabled the application of logic gates in T cells that can mimic the integration of natural signaling pathways and act in a cell intrinsic or extrinsic fashion to precisely target tumor cells and regulate effector functions, potentially overcoming these barriers to effective therapy.

采用定制受体设计的 T 细胞的过继细胞疗法已成为许多恶性肿瘤的有效治疗方法。由于在靶或脱靶效应、癌细胞上的抗原异质性和获得性 T 细胞功能障碍引起的毒性已被确定为阻碍成功治疗的障碍。这篇综述将讨论 T 细胞工程的最新进展，这些进展使得逻辑门能够在 T 细胞中应用，这些逻辑门可以模拟自然信号通路的整合，并以细胞内在或外在的方式发挥作用，以精确靶向肿瘤细胞并调节效应功能，可能克服有效治疗的这些障碍。