All-in-One Nanomedicine: Multifunctional Single-Component Nanoparticles for Cancer Theranostics,Small

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All-in-One Nanomedicine: Multifunctional Single-Component Nanoparticles for Cancer Theranostics
Small ( IF 13.0 ) Pub Date : 2021-09-24 , DOI: 10.1002/smll.202103072
Yu Cai ₁ , Xiaoyi Chen ₁ , Jingxing Si ₁ , Xiaozhou Mou ₁ , Xiaochen Dong ₂

Affiliation

The development of cancer diagnostic imaging and treatment is a major concern worldwide. By integrating imaging and therapy into one theranostic nanoplatform for simultaneously detecting tumors, evaluating the targeting ability and timely monitoring therapeutic responses provide more opportunities for precision medicine. Among various theranostic nanosystems, a series of single-component nanoparticles (NPs) have been developed for “all-in-one” theranostics, which presents the unique properties of facile preparation, simple composition, defined structure, high reproducibility, and excellent biocompatibility. Specifically, utilizing single-component NPs for both diagnostics and therapeutics can reduce the possible numerous untoward side effects and risks to the living body. In this review, the recent progress of multifunctional single-component NPs in the applications of cancer theranostics is systematically summarized. Notably, the structure design, categories of NPs, targeted strategies, biomedical applications, potential barriers, challenges, and prospects for the future clinical practice of this rapidly growing field are discussed.

中文翻译：

多合一纳米药物：用于癌症治疗的多功能单组分纳米颗粒

癌症诊断成像和治疗的发展是全球关注的主要问题。通过将成像和治疗整合到一个同时检测肿瘤的治疗诊断纳米平台，评估靶向能力和及时监测治疗反应为精准医疗提供了更多机会。在各种治疗诊断纳米系统中，已经开发了一系列用于“一体式”治疗诊断的单组分纳米粒子（NPs），具有制备容易、组成简单、结构明确、重现性高、生物相容性好等独特特性。具体来说，将单组分 NPs 用于诊断和治疗可以减少可能对生物体造成的大量不良副作用和风险。在这次审查中，系统总结了多功能单组分纳米颗粒在癌症治疗诊断学应用中的最新进展。值得注意的是，讨论了这个快速发展的领域的结构设计、NPs 类别、靶向策略、生物医学应用、潜在障碍、挑战和未来临床实践的前景。

更新日期：2021-09-24

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