Neuropathic pain highly affects quality of life, well-being, and function. It has recently been shown based on cluster analysis studies that most patients with neuropathic pain may be categorized into 1 of 3 sensory phenotypes: sensory loss, mechanical hyperalgesia, and thermal hyperalgesia. If these phenotypes reflect underlying pathophysiological mechanisms, they may be more relevant for patient management than underlying neurological diagnosis or pain intensity. The aim of this study was thus to examine the impact of these sensory phenotypes on mental health, functionality, and quality of life. Data of 433 patients from the IMI/EuroPain network database were analyzed, and results of HADS-D/A, Pain Catastrophizing Scale, Euro Quality of Life 5D/-VAS, Brief Pain Inventory, and Graded Chronic Pain Scale between the sensory phenotypes were compared using multiple regression analysis. There was no difference in chronic pain grade, pain intensity, depression, or anxiety scores between phenotypes. Pain interference (Brief Pain Inventory) was higher (P = 0.002); self-reported health state lower (Euro Quality of Life 5D VAS, P = 0.02); and problems regarding mobility (P = 0.008), usual activities (P = 0.004), and self-care (P = 0.039) more prominent (EQ5-D) in the sensory loss compared with the thermal hyperalgesia phenotype. Patients with sensory loss also showed higher pain catastrophizing scores (P = 0.006 and 0.022, respectively) compared with the 2 other groups. Sensory phenotype is associated with the impact of neuropathic pain conditions on well-being, daily functionality, and quality of life but is less associated with pain intensity. These results suggest that the somatosensory phenotype should be considered for personalized pain management.

神经性疼痛严重影响生活质量、健康和功能。最近的聚类分析研究表明，大多数神经性疼痛患者可分为 3 种感觉表型中的一种：感觉丧失、机械痛觉过敏和热痛觉过敏。如果这些表型反映了潜在的病理生理机制，那么它们可能比潜在的神经诊断或疼痛强度更适合患者管理。因此，本研究的目的是检查这些感觉表型对心理健康、功能和生活质量的影响。分析了 IMI/EuroPain 网络数据库中 433 名患者的数据，并比较了感觉表型之间的 HADS-D/A、疼痛灾难化量表、欧洲生活质量 5D/-VAS、简要疼痛量表和分级慢性疼痛量表的结果使用多元回归分析进行比较。表型之间的慢性疼痛等级、疼痛强度、抑郁或焦虑评分没有差异。疼痛干扰（简要疼痛量表）较高（P = 0.002）；自我报告的健康状况较低（欧洲生活质量 5D VAS，P = 0.02）；与热痛觉过敏表型相比，感觉丧失中有关活动性（P = 0.008）、日常活动（P = 0.004）和自我护理（P = 0.039）的问题更为突出（EQ5-D）。与其他两组相比，感觉丧失患者的疼痛灾难化评分也更高（分别为P = 0.006 和 0.022）。感觉表型与神经性疼痛状况对健康、日常功能和生活质量的影响相关，但与疼痛强度的相关性较小。这些结果表明，应考虑体感表型进行个性化疼痛管理。