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PEGylated Indium Nanoparticles: A Metallic Contrast Agent for Multiwavelength Photoacoustic Imaging and Second Near-Infrared Photothermal Therapy
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2021-09-24 , DOI: 10.1021/acsami.1c13578 Yu Chen 1 , Haitao Wu 2 , Hu Zhou 1 , Zhaohua Miao 2 , Fengqiu Hong 3 , Qingliang Zhao 3 , Zhenchao Tao 1 , Yan Ma 2 , Weidong Zhao 1 , Zhengbao Zha 2
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2021-09-24 , DOI: 10.1021/acsami.1c13578 Yu Chen 1 , Haitao Wu 2 , Hu Zhou 1 , Zhaohua Miao 2 , Fengqiu Hong 3 , Qingliang Zhao 3 , Zhenchao Tao 1 , Yan Ma 2 , Weidong Zhao 1 , Zhengbao Zha 2
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Indium, a low melting point metal, is well-known for constructing eutectic gallium–indium liquid metal. However, unlike liquid metal nanoparticles, the biomedical applications of metallic indium nanoparticles (In NPs) remain in their infancy. Herein, an ultrasound-assisted liquid-reduction synthesis strategy was developed to prepare PEGylated In NPs, which were then used as a high-performance contrast agent for enhancing multiwavelength photoacoustic imaging and second near-infrared (NIR-II) photothermal therapy of the 4T1 breast tumor. The obtained In NPs depicted remarkable optical absorption from the first near-infrared (NIR-I) to NIR-II region and a high photothermal conversion efficiency of 41.3% at 1064 nm, higher than the majority of conventional NIR-II photothermal agents. Upon injection into the tumor, the photoacoustic intensities of the tumor section post-injection were obviously increased by 2.59-, 2.62-, and 4.27-fold of those of pre-injection by using excitation wavelengths of 750, 808, and 970 nm, respectively, depicting an excellent multiwavelength contrast capability of photoacoustic imaging. In addition, efficient ablation of the 4T1 tumor was achieved through the photothermal performance of PEGylated In NPs under NIR-II laser irradiation. Importantly, as the widely used element in the clinic, In NPs were highly biocompatible in vitro and in vivo. Therefore, this work pioneered the biomedical applications of PEGylated In NPs for cancer diagnosis and treatment.
中文翻译：
聚乙二醇化铟纳米粒子：用于多波长光声成像和二次近红外光热治疗的金属造影剂
铟是一种低熔点金属，因构建共晶镓-铟液态金属而闻名。然而，与液态金属纳米粒子不同，金属铟纳米粒子（In NPs）的生物医学应用仍处于起步阶段。在此，开发了超声辅助液体还原合成策略来制备聚乙二醇化 In NP，然后将其用作高性能造影剂，用于增强 4T1 的多波长光声成像和第二次近红外 (NIR-II) 光热治疗乳腺肿瘤。所获得的In NPs表现出从第一近红外（NIR-I）到NIR-II区域的显着光吸收，并且在1064 nm处具有41.3%的高光热转换效率，高于大多数传统NIR-II光热剂。注射到肿瘤后，使用750、808和970 nm激发波长，注射后肿瘤切片的光声强度分别比注射前明显增加2.59、2.62和4.27倍，描绘了光声成像优异的多波长对比度能力。此外，通过聚乙二醇化In NPs在NIR-II激光照射下的光热性能，实现了4T1肿瘤的有效消融。重要的是，作为临床上广泛使用的元素，In NPs在体外和体内都具有高度的生物相容性。因此，这项工作开创了聚乙二醇化纳米颗粒在癌症诊断和治疗方面的生物医学应用。
更新日期：2021-10-06
中文翻译：
聚乙二醇化铟纳米粒子：用于多波长光声成像和二次近红外光热治疗的金属造影剂
铟是一种低熔点金属，因构建共晶镓-铟液态金属而闻名。然而，与液态金属纳米粒子不同，金属铟纳米粒子（In NPs）的生物医学应用仍处于起步阶段。在此，开发了超声辅助液体还原合成策略来制备聚乙二醇化 In NP，然后将其用作高性能造影剂，用于增强 4T1 的多波长光声成像和第二次近红外 (NIR-II) 光热治疗乳腺肿瘤。所获得的In NPs表现出从第一近红外（NIR-I）到NIR-II区域的显着光吸收，并且在1064 nm处具有41.3%的高光热转换效率，高于大多数传统NIR-II光热剂。注射到肿瘤后，使用750、808和970 nm激发波长，注射后肿瘤切片的光声强度分别比注射前明显增加2.59、2.62和4.27倍，描绘了光声成像优异的多波长对比度能力。此外，通过聚乙二醇化In NPs在NIR-II激光照射下的光热性能，实现了4T1肿瘤的有效消融。重要的是，作为临床上广泛使用的元素，In NPs在体外和体内都具有高度的生物相容性。因此，这项工作开创了聚乙二醇化纳米颗粒在癌症诊断和治疗方面的生物医学应用。
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