More powerful prognostic and diagnostic tools are urgently needed for identifying and treating ovarian cancer (OC), which is the most fatal malignancy in women in developed countries. Circular RNAs (circRNAs) are conservative and stable looped molecules that can regulate gene expression by competing with other endogenous microRNA sponges. This discovery provided new insight into novel methods for regulating genes that are involved in many disorders and cancers. This review focuses on the dysregulated expression of circRNAs as well as their diagnostic and prognostic values in OC. We found that studies have identified twenty-one downregulated circRNAs and fifty-seven upregulated ones. The results of these studies confirm that circRNAs might be potent biomarkers with diagnostic, prognostic and therapeutic target value for OC. We also consider the connection between circRNAs and OC cell proliferation, apoptosis, metastasis, and chemotherapy resistance and sensitivity.

中文翻译：

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CircRNA 作为卵巢癌有效生物标志物：系统范围审查

迫切需要更强大的预后和诊断工具来识别和治疗卵巢癌（OC），这是发达国家女性最致命的恶性肿瘤。环状RNA（circRNA）是保守且稳定的环状分子，可以通过与其他内源性microRNA海绵竞争来调节基因表达。这一发现为调节与许多疾病和癌症有关的基因的新方法提供了新的见解。本综述重点关注 circRNA 的表达失调及其在 OC 中的诊断和预后价值。我们发现研究已经鉴定出 21 个下调的 circRNA 和 57 个上调的 circRNA。这些研究结果证实，circRNA 可能是有效的生物标志物，对 OC 具有诊断、预后和治疗目标价值。我们还考虑了 circRNA 与 OC 细胞增殖、凋亡、转移以及化疗耐药性和敏感性之间的联系。