N6-methyladenosine (m6A) is a prevalent internal modification in eukaryotic RNAs regulated by the so-called “writers”, “erasers”, and “readers”. m6A has been demonstrated to exert critical molecular functions in modulating RNA maturation, localization, translation and metabolism, thus playing an essential role in cellular, developmental, and disease processes. Circular RNAs (circRNAs) are a class of non-coding RNAs with covalently closed single-stranded structures generated by back-splicing. CircRNAs also participate in physiological and pathological processes through unique mechanisms. Despite their discovery several years ago, m6A and circRNAs has drawn increased research interest due to advances in molecular biology techniques these years. Recently, several scholars have investigated the crosstalk between m6A and circRNAs. In this review, we provide an overview of the current knowledge of m6A and circRNAs, as well as summarize the crosstalk between these molecules based on existing research. In addition, we present some suggestions for future research perspectives.

中文翻译：

---

N6-甲基腺苷修饰与环状 RNA 之间的串扰：当前理解和未来方向

N6-甲基腺苷 (m6A) 是真核 RNA 中普遍存在的内部修饰，由所谓的“写入者”、“擦除者”和“读取者”调节。m6A 已被证明在调节 RNA 成熟、定位、翻译和代谢方面发挥关键分子功能，因此在细胞、发育和疾病过程中发挥重要作用。环状RNA（circRNA）是一类非编码RNA，具有通过反向剪接产生的共价闭合单链结构。CircRNAs 还通过独特的机制参与生理和病理过程。尽管几年前就发现了 m6A 和 circRNA，但由于这些年来分子生物学技术的进步，它们引起了越来越多的研究兴趣。最近，一些学者研究了 m6A 和 circRNA 之间的串扰。在本次审查中，我们概述了 m6A 和 circRNAs 的当前知识，并根据现有研究总结了这些分子之间的串扰。此外，我们对未来的研究前景提出了一些建议。