Background Interstitial lung disease (ILD) and pulmonary sarcoidosis are common respiratory diseases with a heterogeneous distribution worldwide. The global burden and temporal trends of ILD and sarcoidosis are rarely explored. Methods Using the classification ‘ILD and pulmonary sarcoidosis’ from the Global Burden of Disease 2019 dataset, we described the age-standardised rates of incidence, mortality, disability-adjusted life-years (DALYs), and their average annual percentage change from 1990 to 2019 by sex, Sociodemographic Index (SDI) and region. Results In 2019, the global incidence and mortality of ILD and pulmonary sarcoidosis were 24.2 million and 169 833 cases, respectively. From 1990 to 2019, the global incidence, deaths and DALYs due to ILD and pulmonary sarcoidosis increased by 118.6%, 166.63% and 122.87% respectively. The global incidence of ILD and pulmonary sarcoidosis was higher in men and was mainly concentrated among persons aged 70‒79 of both sexes. Significant regional differences could be seen in the disease burden of ILD and pulmonary sarcoidosis: since 2006, high-SDI regions had higher age-standardised incidence rates but lower age-standardised death rates compared with the low-SDI regions. Conclusions Our study suggests the incidence, mortality and DALYs from ILD and pulmonary sarcoidosis are increasing globally. To reduce the ongoing burden of this condition, early diagnosis and treatment are vital, and more targeted and specific strategies should be established in high-burden regions. Differences in incidence and mortality across regions may reflect the influence of genetic, environmental, diagnostic, pharmacotherapeutic, and health system factors. Data are available in a public, open access repository. All data relevant to the study are included in the article or uploaded as supplementary information. The full dataset in this study can be obtained from the Institute of Health Metrics and Evaluation website ().

中文翻译：

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1990 年至 2019 年间质性肺病和肺结节病的全球和区域负担：2019 年全球疾病负担研究的结果

背景 间质性肺病 (ILD) 和肺结节病是常见的呼吸系统疾病，在全球范围内分布不均。很少探讨 ILD 和结节病的全球负担和时间趋势。方法 使用 2019 年全球疾病负担数据集中的“ILD 和肺结节病”分类，我们描述了从 1990 年到2019 年按性别、社会人口学指数 (SDI) 和地区划分。结果2019年全球ILD和肺结节病的发病率和死亡率分别为2420万和169833例。从1990年到2019年，全球ILD和肺结节病的发病率、死亡人数和DALYs分别增加了118.6%、166.63%和122.87%。全球 ILD 和肺结节病的发病率在男性中较高，主要集中在 70-79 岁的男女人群中。在 ILD 和肺结节病的疾病负担方面可以看到显着的区域差异：自 2006 年以来，与低 SDI 地区相比，高 SDI 地区的年龄标准化发病率较高，但年龄标准化死亡率较低。结论 我们的研究表明，ILD 和肺结节病的发病率、死亡率和 DALYs 在全球范围内呈上升趋势。为了减轻这种疾病的持续负担，早期诊断和治疗至关重要，应在高负担地区制定更有针对性和具体的策略。不同地区发病率和死亡率的差异可能反映了遗传、环境、诊断、药物治疗和卫生系统因素的影响。数据可在公共、开放访问的存储库中获得。所有与研究相关的数据都包含在文章中或作为补充信息上传。本研究中的完整数据集可从健康指标与评估研究所网站获得（）。