Development of a Portable Method for Serum Lithium Measurement Based on Low-Cost Miniaturized Ultrasonic Nebulization Coupled with Atmospheric-Pressure Air-Sustained Discharge,Analytical Chemistry

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Development of a Portable Method for Serum Lithium Measurement Based on Low-Cost Miniaturized Ultrasonic Nebulization Coupled with Atmospheric-Pressure Air-Sustained Discharge
Analytical Chemistry ( IF 6.7 ) Pub Date : 2021-09-24 , DOI: 10.1021/acs.analchem.1c03133
Jun-Hang Dong _{1,

2} , Chun Yang ₁ , Han-Qing Ding _{1,

2} , Peng-Ju Xing ₁ , Fei-Yang Zhou _{1,

2} , Huan Tian ₂ , Xing Liu ₁ , Hong-Tao Zheng ₂ , Sheng-Hong Hu ₁ , Zhen-Li Zhu _{1,

2}

Affiliation

An accurate, rapid but cheap, and portable method for monitoring of serum lithium (Li) is highly desirable for mental patients who take Li medicine for treatment. Conventional techniques are usually bulky, costly, and cannot provide on-site real-time measurements. Herein, a miniaturized, reliable, cost-effective, and portable optical emission method for rapid and sensitive determination of serum Li was developed based on a combination of miniaturized ultrasonic nebulization (MUN) and a low-power (≈22 W) atmospheric-pressure air-sustained discharge (APAD) excitation source. The proposed method eliminates the use of any compressed gas or pump and can achieve serum Li detection within 40 s with low sample consumption (less than 20 μL serum). Except for dilution with water, no extra treatment is needed for serum Li analysis by MUN-APAD-OES. In addition, it offers a significant advantage of good tolerance to the coexisting high concentration of Na, K, Ca, and Mg, which is in contrast with the obvious matrix effect encountered in conventional inductively coupled plasma optical emission spectrometry (ICP-OES). Different operating parameters affecting the performance of MUN-APAD-OES were evaluated. Under optimized conditions, the detection limit of Li (670.8 nm) was calculated to be 0.6 μg L^–1 (6 μg L^–1 in serum). Finally, the accuracy of the proposed method was validated by the analysis of two certified reference materials (Seronorm serum L-1 and L-2 RUO), six real human serum samples, and eight real animal serum samples. All of the results indicate that the low-cost and low-power MUN-APAD-OES provides a promising reliable method for on-site serum Li measurement and may also be extended to other elements.

中文翻译：

基于低成本微型超声雾化和常压空气持续放电的便携式血清锂测量方法的开发

对于服用锂药治疗的精神病患者来说，一种准确、快速但廉价且便携的血清锂（Li）监测方法是非常需要的。传统技术通常体积庞大、成本高昂，并且无法提供现场实时测量。在此，基于小型化超声雾化 (MUN) 和低功率 (≈22 W) 大气压相结合，开发了一种小型化、可靠、经济、便携式的光发射方法，用于快速、灵敏地测定血清锂空气持续放电 (APAD) 激发源。所提出的方法无需使用任何压缩气体或泵，并且可以在 40 秒内以低样品消耗（少于 20 μL 血清）实现血清 Li 检测。除了用水稀释外，MUN-APAD-OES 分析血清锂不需要额外处理。此外，它具有对共存的高浓度 Na、K、Ca 和 Mg 具有良好耐受性的显着优势，这与传统电感耦合等离子体发射光谱 (ICP-OES) 中遇到的明显基质效应形成对比。对影响 MUN-APAD-OES 性能的不同操作参数进行了评估。在优化条件下，计算出 Li (670.8 nm) 的检出限为 0.6 μg L^–1（血清中6 μg L ^–1）。最后，通过对两种有证标准物质（Seronorm 血清 L-1 和 L-2 RUO）、6 种真实人血清样品和 8 种真实动物血清样品的分析，验证了所提出方法的准确性。所有结果表明，低成本、低功耗的 MUN-APAD-OES 为现场血清 Li 测量提供了一种有前途的可靠方法，也可以扩展到其他元素。

更新日期：2021-10-06

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