Vanadium is considered to be biologically significant and several vanadium IV & V complexes have successfully been studied as chemotherapeutic agents like insulin mimetic, antibacterial, antioxidant, and anticancer activities. The divergent ligand systems also play a pivotal role in designing the metal complex with desired properties. Thus, the combination of both with their synergistic advantages results in a potential drug candidate. Different mechanistic pathways have been proposed to explain the antitumor effects of vanadium complexes, including induction of tyrosine residues phosphorylation, inhibition of key protein tyrosine phosphatases (PTPases), which in turn promote the activation of the extracellular regulated kinase cascading (ERK) pathway. In the current review, we have summarized the work on vanadium (V) complexes based on different ligand systems and their biological significance as an anticancer lead compound.

钒被认为具有生物学意义，并且已经成功地研究了几种钒 IV 和 V 复合物作为化学治疗剂，如胰岛素模拟物、抗菌、抗氧化和抗癌活性。发散配体系统在设计具有所需特性的金属配合物方面也发挥着关键作用。因此，两者的结合及其协同优势产生了潜在的候选药物。已经提出了不同的机制途径来解释钒配合物的抗肿瘤作用，包括诱导酪氨酸残基磷酸化、抑制关键蛋白酪氨酸磷酸酶 (PTPases)，进而促进细胞外调节激酶级联 (ERK) 途径的激活。在目前的审查中，