A sulfatase-activatable AIEgen nanoprobe for inhalation imaging-guided surgical excision of lung cancer,Chemical Engineering Journal

当前位置： X-MOL 学术 › Chem. Eng. J. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

A sulfatase-activatable AIEgen nanoprobe for inhalation imaging-guided surgical excision of lung cancer
Chemical Engineering Journal ( IF 13.3 ) Pub Date : 2021-09-24 , DOI: 10.1016/j.cej.2021.132514
Yanqi Xu _{1,

2} , Mengyuan Cui ₂ , Wancun Zhang ₁ , Tianguang Liu ₂ , Xiangyu Ren ₂ , Yueqing Gu ₂ , Chongzhao Ran ₃ , Jing Yang ₂ , Peng Wang _{1,

2}

Affiliation

Tracking sulfatase in the living organism is beneficial for the diagnosis of sulfatase-overexpressed cancer and understanding the pathological activities of sulfatase. A nanoprobe () with AIE signal amplification for imaging of sulfatase activity was rationally developed. The probe could be self-assembled into nanoparticles in the aqueous solution due to the hydrophobic AIE core and hydrophilic sulfatase-recognition unit. could be activated by the catalytic domain of sulfatase to afford the AIEgen , which can emit the aggregation-induced fluorescence and further bind to the hydrophobic site of sulfatase resulted in a stronger AIE signal. The nanoprobe exhibited a fast response and high sensitivity to sulfatase. Moreover, it was successfully employed in detecting the endogenous overexpressed sulfatase in tumor cells and tumor tissue. Importantly, the sulfatase activity in a mouse metastatic lung tumor model was imaged using by pulmonary administration, indicating has the potential to detect cancer cells as the inhalation contrast medium.

中文翻译：

硫酸酯酶激活的 AIEgen 纳米探针用于吸入成像引导的肺癌手术切除

追踪活体中的硫酸酯酶有助于诊断硫酸酯酶过度表达的癌症和了解硫酸酯酶的病理活性。合理开发了一种具有 AIE 信号放大功能的用于硫酸酯酶活性成像的纳米探针 ()。由于疏水性AIE核心和亲水性硫酸酯酶识别单元，探针可以在水溶液中自组装成纳米颗粒。可以被硫酸酯酶的催化结构域激活，产生AIEgen，它可以发射聚集诱导的荧光，并进一步与硫酸酯酶的疏水位点结合，产生更强的AIE信号。该纳米探针对硫酸酯酶表现出快速响应和高灵敏度。此外，它还成功用于检测肿瘤细胞和肿瘤组织中内源性过表达的硫酸酯酶。重要的是，通过肺部给药对小鼠转移性肺肿瘤模型中的硫酸酯酶活性进行成像，表明具有作为吸入造影剂检测癌细胞的潜力。

更新日期：2021-09-24

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11