Healing of gastrointestinal ulcers after Hemospray application was reported in literature. The pathophysiological mechanism of action of hemostatic powders is not elucidated so far. A prospective animal model was performed to evaluate the effect of Hemospray application on the healing process of artificially induced ulcers of the upper and lower gastrointestinal tract. In 10 pigs, 20 ulcers were created in each the upper and the lower gastrointestinal tract by endoscopic mucosal resection. 50% of the pigs were immediately treated with Hemospray application, the others were not treated. Ulcer size was measured endoscopically on day 0, 2, and 7. On day 7 the ulcers were histopathological evaluated for capillary ingrowth and the thickness of the collagen layer. After 7 days the sizes of the ulcers decreased significantly (stomach: − 22.8% with Hemospray application, − 19% without Hemospray application; rectum: − 50.8% with Hemospray application, − 49.5% without Hemospray application; p = 0.005–0.037), but without significant difference between both groups. This study shows no significant effect of the hemostatic powder Hemospray on ulcer healing in the upper and lower gastrointestinal tract compared with untreated controls, neither harmful nor beneficial. However, some trends merit further trials in patients and may indicate a possible mechanism of accelerated mucosal healing.

文献报道了使用喷血剂后胃肠溃疡的愈合。止血粉的病理生理作用机制目前尚未阐明。进行前瞻性动物模型以评估 Hemospray 应用对人工诱导的上消化道和下消化道溃疡愈合过程的影响。在 10 头猪中，通过内镜下粘膜切除术，在上消化道和下消化道各产生了 20 个溃疡。50% 的猪立即使用 Hemospray 进行治疗，其他猪没有治疗。在第0、2和7天通过内窥镜测量溃疡大小。在第7天，针对毛细血管向内生长和胶原层厚度对溃疡进行组织病理学评估。7 天后，溃疡的大小显着减小（胃：- 22。8% 使用 Hemospray， - 19% 不使用 Hemospray；直肠：- 50.8% 使用 Hemospray，- 49.5% 不使用 Hemospray；p  = 0.005–0.037），但两组之间没有显着差异。该研究表明，与未经治疗的对照组相比，止血粉 Hemospray 对上消化道和下消化道溃疡愈合没有显着影响，既无害也无益。然而，一些趋势值得在患者中进一步试验，并可能表明加速粘膜愈合的可能机制。