Magnetic drug targeting (MDT) is a new and effective therapeutic technique to treat some diseases. In this method, the transfer of magnetic particles labeled with therapeutic agents in the presence of a magnetic field increases the efficiency of treatment. In this study, targeted delivery of endothelial cells containing magnetic particles in a stenosed curved artery for solid and elastic wall states was investigated, using an external magnetic field. The Eulerian-Lagrangian approach and the Eulerian-Lagrangian coupled FSI technique were employed to solve the continuum equations and track the trajectory of cells in a rigid and elastic artery, respectively. The influence of parameters was investigated, such as the mass of magnetic particles injected in each cell, the magnetic field strength, the injection time, the occlusion percentage, and the chord length of stenosis on the capture efficiency (CE). The effect of wall elasticity on CE was also studied. The results reveal that by increasing the mass of magnetic particles injected in each cell from 20 pg to 300 pg, the cells absorption at the target site is enhanced from 17% to 43%. Also, a slight increase in the magnetic field strength has a significant effect on increasing the CE. The injection of cells in a complete period of the cardiac cycle provides greater CE than other systole and diastole intervals. Examining the stenosis morphology shows that reducing the occlusion percentage from 40% to 20% and the chord length of stenosis from 70° to 30° results in an increase in the CE about 6% and 3% for 300 pg of magnetic particles in each cell, respectively. The trend of CE changes is the same for elastic artery and the rigid artery. However, in all cases, the elastic artery has a higher CE than the rigid artery. The obtained results can be useful for the treatment of atherosclerosis in curved vessels using targeted cell delivery.

磁性药物靶向（MDT）是一种治疗某些疾病的新型有效治疗技术。在该方法中，在存在磁场的情况下转移用治疗剂标记的磁性粒子提高了治疗效率。在这项研究中，使用外部磁场研究了在狭窄的弯曲动脉中针对固体和弹性壁状态的含有磁性颗粒的内皮细胞的靶向递送。欧拉-拉格朗日方法和欧拉-拉格朗日耦合 FSI 技术分别用于求解连续方程和跟踪细胞在刚性和弹性动脉中的轨迹。研究了参数的影响，如注入每个细胞的磁性粒子的质量、磁场强度、注入时间、闭塞百分比、和狭窄的弦长对捕获效率 (CE) 的影响。还研究了壁弹性对 CE 的影响。结果表明，通过将注入每个细胞的磁性粒子的质量从 20 pg 增加到 300 pg，靶位点的细胞吸收从 17% 提高到 43%。此外，磁场强度的轻微增加对增加 CE 有显着影响。在心动周期的完整时期注射细胞比其他收缩和舒张间隔提供更大的 CE。检查狭窄形态表明，对于每个细胞中 300 pg 磁性颗粒，将闭塞百分比从 40% 降低到 20%，将狭窄的弦长从 70° 降低到 30° 导致 CE 增加约 6% 和 3% ， 分别。弹性动脉和刚性动脉的CE变化趋势相同。然而，在所有情况下，弹性动脉比刚性动脉具有更高的 CE。获得的结果可用于使用靶向细胞递送治疗弯曲血管中的动脉粥样硬化。