Light-Induced Modulation of Chiral Functions in G-Quadruplex–Photochrome Systems,The Journal of Physical Chemistry Letters

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Light-Induced Modulation of Chiral Functions in G-Quadruplex–Photochrome Systems
The Journal of Physical Chemistry Letters ( IF 4.8 ) Pub Date : 2021-09-23 , DOI: 10.1021/acs.jpclett.1c02207
Marta Dudek ₁ , Marco Deiana ₂ , Kinga Szkaradek ₃ , Mikołaj J Janicki ₃ , Ziemowit Pokładek ₁ , Robert W Góra ₃ , Katarzyna Matczyszyn ₁

Affiliation

The design of artificially engineered chiral structures has received much attention, but the implementation of dynamic functions to modulate the chiroptical response of the systems is less explored. Here, we present a light-responsive G-quadruplex (G4)-based assembly in which chirality enrichment is induced, tuned, and fueled by molecular switches. In particular, the mirror-image dependence on photoactivated azo molecules, undergoing trans-to-cis isomerization, shows chiral recognition effects on the inherent flexibility and conformational diversity of DNA G4s having distinct handedness (right- and left-handed). Through a detailed experimental and computational analysis, we bring compelling evidence on the binding mode of the photochromes on G4s, and we rationalize the origin of the chirality effect that is associated with the complexation event.

中文翻译：

G-四链体-光致变色系统中手性函数的光诱导调制

人工工程手性结构的设计受到了广泛关注，但用于调节系统手性光学响应的动态函数的实现却很少被探索。在这里，我们提出了一种基于光响应 G 四链体 (G4) 的组装体，其中手性富集是由分子开关诱导、调节和推动的。特别是，对光活化偶氮分子的镜像依赖性，经历反式到顺式异构化，显示出对具有不同旋性（右旋和左旋）的DNA G4的固有灵活性和构象多样性的手性识别效应。通过详细的实验和计算分析，我们为光致变色剂在 G4 上的结合模式提供了令人信服的证据，并且我们合理化了与络合事件相关的手性效应的起源。

更新日期：2021-10-07

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