Nickel-Catalyzed Intramolecular Hydroalkenylation of Imines,Organic Letters

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Nickel-Catalyzed Intramolecular Hydroalkenylation of Imines
Organic Letters ( IF 4.9 ) Pub Date : 2021-09-24 , DOI: 10.1021/acs.orglett.1c02908
Wei-Min Feng ₁ , Tian-Yu Li ₁ , Li-Jun Xiao ₁ , Qi-Lin Zhou ₁

Affiliation

A ligand-enabled nickel-catalyzed intramolecular hydroalkenylation of imines with unactivated alkenes has been developed. A variety of five- and six-membered cyclic allylic amines were synthesized in high yields. The use of both wide-bite-angle diphosphine ligand and Brønsted acid is crucial for realizing the reaction. Preliminary investigation of the asymmetric intramolecular hydroalkenylation of imines shows promising potential for the application of the method in the synthesis of enantio-enriched cyclic allylic amines.

中文翻译：

亚胺的镍催化分子内加氢烯基化

已开发出一种配体使能的镍催化亚胺与未活化烯烃的分子内加氢烯基化。以高产率合成了各种五元和六元环状烯丙胺。广角二膦配体和布朗斯台德酸的使用对于实现反应至关重要。对亚胺的不对称分子内加氢烯基化的初步研究表明，该方法在合成富含对映体的环状烯丙基胺中具有广阔的应用前景。

更新日期：2021-10-15

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