Heterologous Production of Unnatural Flavipucine Family Products Provides Insights into Flavipucines Biosynthesis,Organic Letters

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Heterologous Production of Unnatural Flavipucine Family Products Provides Insights into Flavipucines Biosynthesis
Organic Letters ( IF 4.9 ) Pub Date : 2021-09-23 , DOI: 10.1021/acs.orglett.1c02566
Guangzheng Wei _{1,

2} , Xian Shu _{1,

2} , Yongpeng Yao ₁ , Kexin Zhang _{1,

2} , Jun Zhang ₁ , Shu-Shan Gao ₁

Affiliation

Heterologous expression of the flavipucine biosynthetic gene cluster in Aspergillus nidulans led to the production of flavipucine (1) and dihydroisoflavipucine (3), as well as six unusual flavipucine related products containing three classes of heterocycles. This combined with gene inactivation, chemical complementation, and transcriptome analysis demonstrated unprecedented ways to form 2-pyridone and 2-pyrone structures by the oxidative rearrangements of pyrrolinone precursors as well as provided insights into the biosynthesis of this important class of natural products.

中文翻译：

非天然 Flavipucines 家族产品的异源生产提供了对 Flavipucines 生物合成的见解

Flavipucine 生物合成基因簇在Aspergillus nidulans 中的异源表达导致产生 flavipucine ( 1 ) 和 dihydroisoflavipucine ( 3 )，以及包含三类杂环的六种不同寻常的 flavipucine 相关产品。这与基因失活、化学互补和转录组分析相结合，展示了通过吡咯啉酮前体的氧化重排形成 2-吡啶酮和 2-吡喃酮结构的前所未有的方法，并提供了对这类重要天然产物的生物合成的见解。

更新日期：2021-10-15

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