Genetic analysis of the association between alcohol, cocaine, and opiate addiction and variable number tandem repeat (VNTR) polymorphisms in monoamine oxidase B (MAOB) and serotonergic 5-hydroxytryptamine (serotonin) receptor 1B and 2C (HTR1B 21 and HTR2C) pathway genes was performed in a sample of 302 polyconsumers. Our genetic association analysis revealed a significant association between a 184 base pair (bp) VNTR polymorphism in the MAOB gene and addiction to cocaine and opiates. This work highlights new genetic marker associations in cocaine and opiate polyconsumer addictions. These data help to clarify and quantify the complex role of genetics in addictive disorders, as well as their future contribution to the prevention (genetic counselling), diagnosis (genetic diagnosis of vulnerability), and treatment (pharmacogenomics) of these disorders.

中文翻译：

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MAOB 可变数串联重复多态性与多消费者中可卡因和阿片类药物成瘾之间的关联

酒精、可卡因和阿片类药物成瘾与单胺氧化酶 B (MAOB) 和血清素能 5-羟色胺 (5-羟色胺) 受体 1B 和 2C (HTR1B 21 和 HTR2C) 通路基因中可变数量串联重复 (VNTR) 多态性之间关联的遗传分析是在 302 个多消费者样本中进行。我们的遗传关联分析揭示了 MAOB 基因中 184 碱基对 (bp) VNTR 多态性与可卡因和阿片类药物成瘾之间的显着关联。这项工作突出了可卡因和鸦片类多消费成瘾中新的遗传标记关联。这些数据有助于阐明和量化遗传学在成瘾性疾病中的复杂作用，以及它们未来对这些疾病的预防（遗传咨询）、诊断（脆弱性的遗传诊断）和治疗（药物基因组学）的贡献。