CAR T cell therapies have made great strides in the clinic; however, multiple hurdles limit the efficacy of this approach for solid tumors. A new study has developed an optimized, dual-targeting CAR T cell that overcomes several of these challenges by enhancing T cell persistence and reducing therapy escape due to antigen loss.

中文翻译：

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分离信号进一步推动 CAR

CAR T细胞疗法在临床上取得了长足的进步；然而，多重障碍限制了这种方法对实体瘤的疗效。一项新的研究开发了一种优化的双靶向 CAR T 细胞，该细胞通过增强 T 细胞的持久性和减少由于抗原丢失导致的治疗逃逸来克服其中的几个挑战。