Mutations in cyp51A gene are known as main mechanisms of azole resistance in Aspergillus fumigatus, whereas azole-susceptible strains also carry cyp51A mutations (polymorphisms). The polymorphisms found in Europe mainly consist of two combinations of mutations, that is combinations of five single-nucleotide polymorphisms (SNPs) of cyp51A, referred to as cyp51A-5SNPs, and combinations of three SNPs of cyp51A, referred to as cyp51A-3SNPs. Few studies have compared the distributions of cyp51A polymorphisms between different regions.

中文翻译：

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日本与国外烟曲霉cyp51A多态性的遗传差异

cyp51A基因的突变被认为是烟曲霉中唑类抗性的主要机制，而唑类敏感菌株也携带cyp51A突变（多态性）。在欧洲发现的多态性主要由两种突变组合组成，即cyp51A的5个单核苷酸多态性(SNPs)的组合，称为cyp51A -5SNPs，和cyp51A的3个SNPs的组合，称为cyp51A -3SNPs。很少有研究比较不同区域之间cyp51A多态性的分布。